Difluorocarbene-based [4 + 1] Cycloaddition Strategy for Synthesizing Derivatives of 5-Fluorinated Thiazoles and Oxazoles
نویسندگان
چکیده
When treated with difluorocarbene, which was generated from FSO2CF2CO2SiMe3 a 1,8-bis(dimethylamino)naphthalene catalyst, N-(thioacyl)amidines underwent [4 + 1] cycloaddition to afford the corresponding amino-substituted 5,5-difluorothiazolines. Both dehydrofluorination and Hofmann elimination/SN2?-type reaction sequence enabled aromatization of obtained products, affording 5-fluorothiazoles. The strategy also applied N-acylamidines, 5-fluorooxazole derivatives. On treatment successfully sequence, facilitated products provide N-acylamidines
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ژورنال
عنوان ژورنال: Chemistry Letters
سال: 2022
ISSN: ['0366-7022', '1348-0715']
DOI: https://doi.org/10.1246/cl.220212